A low carbohydrate diet, even so far as going to a ketogenic diet, may be helpful
C.GoldsworthyB.GogaA.LetoileN
If side effects worsen after switching to split dosing, it may indicate a measurement error resulting in inadvertently higher individual doses, or it may suggest that your side effects are not primarily driven by peak concentration
There are practical reasons too: B can be unstable if mixed with certain other vitamins in solution, and dosing schedules for B deficiency (pernicious anemia, for instance) may differ
If you need more suggestions about buffer conditions, check out this handy chemical compatibility chart for our glutathione agarose beads
Fast injection increases discomfort and can cause the solution to track back along the needle path