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Collectively, it may be hypothesized that obesity induces feedback inhibition of pituitary GH secretion by increasing non-fasting serum FFA levels and the associated insulin resistance that causes compensatory intra-portal hyperinsulinemia and IGFBP-1 suppression, with the net result being low GH and normal IGF-I levels
Baeshen NA, Baeshen MN, Sheikh A, Bora RS, Ahmed MM, Ramadan HA, et al
Bim (1:1000, Sigma-Aldrich GmbH, Buchs, Switzerland), tBid (1:1000, 30 ), cleaved caspase 3 (1:1000, Cell Signaling Technology, Bioconcepts, Allschwil, Switzerland), cytochrome c (1:1000, BD Biosciences, Allschwil, Switzerland), porin (1:2000, Calbiochem, Merck, Zug, Switzerland) and FLIP (1:1000, Enzo life science, Lausen, Switzerland) were detected by incubation of membranes with the respective primary antibodies and corresponding horseradish peroxidase-labeled secondary antibodies
Bhatt, A
