It can allow for more gradual escalation of doses when starting treatment and reduce the GI side effects that most commonly occur during this period, says Kushner
These actions contribute to significant weight reduction combined with lifestyle changes such as regular exercise and a reduced-calorie diet
These risks include dosing errors, sterility concerns, counterfeit products, altered bioavailability, and reduced clinician oversight in some settings
This matters for BMI discussions because people starting at lower BMIs may reach a normal weight range faster on tirzepatide, which raises questions about treatment duration that our guide on GLP-1 treatment duration addresses in detail
J Clin Invest (1987) 79(2):6169.10.1172/JCI112855 4 SasakiSMiyatsukaTMatsuokaTATakaharaMYamamotoYYasudaTet alActivation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice
AM, PJ, DB, BD, CW, KA, MP, HG, EG, KS, and PA: review and editing