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It can allow for more gradual escalation of doses when starting treatment and reduce the GI side effects that most commonly occur during this period, says Kushner

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This matters for BMI discussions because people starting at lower BMIs may reach a normal weight range faster on tirzepatide, which raises questions about treatment duration that our guide on GLP-1 treatment duration addresses in detail

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J Clin Invest (1987) 79(2):6169.10.1172/JCI112855 4 SasakiSMiyatsukaTMatsuokaTATakaharaMYamamotoYYasudaTet alActivation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice

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AM, PJ, DB, BD, CW, KA, MP, HG, EG, KS, and PA: review and editing

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