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Pathologic features include pain, immobility, and inflammation

Improvements in sexual quality of life after moderate weight loss in obese men: the SCALE Obesity and Prediabetes trial

Diurnal rhythms of plasma GLP-1 levels in normal and overweight/obese subjects: lack of effect of weight loss

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These reports vary widely in severity and timing, with some patients noting symptoms shortly after starting the medication or following dose increases, while others report intermittent or persistent discomfort throughout treatment