Later studies showed similar benefits for people without diabetes, but who had obesity or elevated heartdisease risk
Several factors influence how noticeable skin laxity becomes: Loss of fat that once helped fill out the skin Natural declines in collagen and elastin with age Genetics and baseline skin quality How much weight is lost and how quickly Areas like the abdomen, arms, thighs, neck, and lower face are especially prone to laxity because they rely heavily on structural support rather than muscle tone alone
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It mostly affects women and can impact daily life
The action is self-limiting as when the increased insulin release reduces plasma glucose, the ability of GLP-1 to act is turned off (44)
However, the degree of metabolic change at these lower doses remains uncertain