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To investigate the mechanisms for APAP-induced necrotic hepatocytes death, we studied the JNK involved in the signal transduction in the hepatic tissues

3numerous confluent changes): (a) the hemorrhagic zone, (b) edema, (c) the loss of neurons in anterior horn and intermediate gray matter, (d) vacuoles, and (e) the loss of lateral and posterior spinal column tracts

As has been shown for both l-arginine and l-ornithine, circulating concentrations of l-citrulline return to baseline within 8 h [11])

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