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6.6.3 Integrative strategies and future directions Combining TCM with conventional antidepressants may offer synergistic benefits through complementary effects on gut microbiota composition and metabolism (Huang M

Gut microbiota has bidirectional communication with HPA axis: certain microbial metabolites can attenuate it whereas translocated microbial antigens and exerted cytokines or prostaglandins productions activate it [95]

Compared with the CON group, 104 metabolites were significantly upregulated and 89 metabolites were significantly downregulated in the WKY group (Fig

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Each session constitutes a part of the overall treatment plan and contributes to the cumulative cost of the procedure