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Postprandial hypoglycaemia after gastric bypass in type 2 diabetes: pathophysiological mechanisms and clinical implications The authors conclude "that post-bypass PPHG occurs frequently in individuals with a history of type 2 diabetes, often without warning symptoms, and expose its complex pathogenetic mechanisms, revealing potential therapeutic targets." In Diabetologia: The underlying mechanisms of postbariatric hypoglycemia are multifactorial and related to the anatomic reconfiguration of the gastrointestinal tract causing accelerated intestinal nutrient delivery and transit, leading to augmented glucose absorption and exaggerated release of insulinotropic GLP-1, which together ensue severe hyperinsulinaemia (insulin overshoot), leading to postprandial hypoglycemia 1 to 3 h after meal intake