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doi: 10.1113/JP283259 91 BarlampaDBompoulaMSBargiotaAKalantaridouSMastorakosGValsamakisG

The cardiovascular and renal benefits of GLP-1 drugs are real and now well documented in outcome trials, but the receptor biology behind them is more indirect than it first appears

This depletion is associated with impaired immune homeostasis, disrupted intestinal barrier integrity, and heightened inflammation

Salamun et al

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All of the conditions in blue below indicate signficant reductions in risk for those taking GLP-1 drugs compared to usual care (indicated by hazard ratios that are less than 1, so to the left of the dotted line)