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One of the first descriptions of the clinical application of cryotherapy to produce local blocking of peripheral nerves was in 1976 by Lloyd [14]

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3.2 Potential biomarkers associated with PCa screening, early detection, and diagnosis A total of 20 potential biomarkers with possible applications in the screening, early detection, and diagnosis of PCa were identified in 13 articles from four countries ( Table 3 , Supplementary Table 3 ) (111123)

Additionally, through further immunoblot analysis of tumor tissues, we observed that Formononetin treatment led to a reduction in the expression of intracellular ferroptosis-related proteins GPX4, and xCT (Figure 2K)