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Description

It oxidizes rapidly in healthy individuals to benzoic acid, conjugated with glycine in the liver, and excreted as hippuric acid

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High-dose niacin raises blood glucose by reducing insulin sensitivity through a free fatty acid rebound mechanism a direct pharmacodynamic opposition to GLP-1's glucose-lowering action, most clinically significant for patients with type 2 diabetes

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Wegovy is also available in higher doses than Ozempic

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