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Similarly, serum T4 concentration was significantly increased in the groups injected with Fe 3 O 4 -NPs, Cu-NPs, and ZnO-NPs compared to the control group by 31.38, 31.21, and 26.17%, respectively

Chugani 1999)

While App knockin mouse shows no significant neurodegeneration and neuronal loss, it shows synaptic loss and reduction of a part of neuronal cells including active place cells around A plaques 41,60

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