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Through these combined mechanisms, phlorizin helps preserve dopaminergic neuron integrity and reduces vulnerability to metabolic and inflammatory stressors in PD ( Several plant-derived phytochemicals have been shown to influence the incretin system, specifically by modulating dipeptidyl peptidase-4 (DPP-IV) activity and thereby prolonging the half-life of GLP-1, GIP, and other incretin hormones

doi: 10.1002/biof.1823 275 AlbakerABAlhusainiAMAlbadraniHMSarawiWSAlsabhanJFMansyTWet al

Patients with a documented osteoporosis diagnosis before or on the baseline date were excluded from the study

Overall, given the high cost and uncertainties, I would not recommend this product

Lancet 370 , 415426

Funding: This guideline was funded by the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (grant number ZYGD18022)