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The toxicity related to the generation of these reactive thio-intermediates remains unclear, in particular in the case of acute intoxication, and has never been studied so far in the case of APAP

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For this purpose, hG6PD was initially purified 557-fold at a yield of 51.43% using 2,5-adenosine diphosphate (ADP) sepharose 4B affinity gel chromatography

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It is known to provide a physiologically acceptable electrical current(0.1-1.0 mA/cm 2 ) using an electrode of the same polarity to drive charged permeants across the SC through its potential gradient [249, 250]