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In intact HepG2 cells, the pan-flavoenzyme inhibitor, DPI, prevented the NFT-stimulated increase in glutathione levels, indicating the involvement of one or more of these enzymes in NFT-dependent activation of Nrf2 (Fig

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347,348,349 Similarly, MSU promotes the expression of other cytokines, such as interleukin-6 (IL-6), tumor necrosis factor- (TNF-), and interferon gamma (IFN-), and chemokines, such as monocyte chemotactic protein-1 (MCP-1)

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Whether reduction in gastric emptying is involved in the acute and long-term metabolic effects of OXM is not yet clear