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It promotes satiety and helps with blood sugar control but also slows down the entire gastrointestinal tract , leading to: Reduced peristalsis (gut contractions) Longer intestinal transit time Harder, drier stools Reduced Caloric and Fiber Intake Patients on GLP-1 medications often eat significantly less food due to appetite suppression

(2) Extending life expectancy includes reducing overall organ damage that occurs with DS and contributes to patients shorter life spans

Natural history of thyroid function in diabetics with impaired thyroid reserve: a four year controlled study

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These effects may be more noticeable during dose changes