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Deposition of harmful protein aggregates in neuronal cells causes age-related neurodegenerative diseases such as Alzheimers disease and Parkinsons disease, which damage cognitive ability and memory loss (Sonawane et al., 2021)

a moderately low carbohydrate diet (30-40% TEI)

As a representative molecule of NAMPs/DAMPs/PAMPs, the nuclear protein high-mobility group box protein 1 (HMGB1) plays an important role in CNS-related pathologies by being released from damaged cells 24

The mean age at the time of the genetic test was 42 years

It is regulated by fatty acid binding-proteins (FABPs)

In a rst study [ 128 ], nine patients (eight males and one female) receiving choline esterase inhibitors were treated with ALA (600 mg/day) for about 1 year