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BAs are essential endocrine molecules that control metabolic homeostasis via nuclear and membrane-bound receptors, Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5), respectively

In an uncontrolled study in people with T2D, liraglutide initially lowered eGFR (35), but this result was not confirmed in placebo-controlled studies that assessed mGFR and kidney hemodynamic function by gold-standard tracer methods (36)

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In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs

Rybelsus (oral semaglutide) : The first oral GLP-1 medication approved for type 2 diabetes