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Receptor Pharmacology Applied to characterize receptor-level interactions and signaling kinetics in controlled laboratory environments

Prog.Neuropsychopharmacol.Biol.Psychiatry 6-1-2011;35(4):953-958

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It inhibits NOTCH1 signaling by using its GCT activity to cleave a -glutamyl-cysteine bond at glutamate 1669 of the immature NOTCH receptor, thereby preventing the essential S1 cleavage and subsequent activation ( FIGURE 6 The physiological importance of this mechanism is underscored by severe developmental phenotypes upon its disruption

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that supports DNA synthesis, red blood cell formation, and neurological function