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Description

In the SURMOUNT-1 trial, tirzepatide users saw a 10.9% lean mass reduction over 72 weeks, while approximately 74% of total body weight lost came from fat mass

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So when we give them in pharmacologic doses, like in Mounjaro, those effects are enhanced. But even though the medication is mimicking hormones that are already present in the body, getting a bigger dose of them at once may lead to side effects

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Tesamorelin: FDA-approved for reducing visceral adipose tissue in HIV-associated lipodystrophy, but widely studied for its role in fat loss, metabolic improvement, and GH stimulation

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Plateaus and Long-Term Results Most patients experience periods where weight loss temporarily slows: Plateaus are normal and expected during any weight loss journey Adjustments to diet, exercise or medication dosage may help overcome plateaus Long-term studies show that continued use helps maintain weight loss Periodic reassessment helps identify when strategy changes might be beneficial Studies show that patients who remained on semaglutide for more than a year maintained most of their weight loss, while those who discontinued the medication typically regained some weight

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