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Consequently its metabolites such as carbon monoxide (CO), biliverdin (BV) and bilirubin (BR) could become parts of a therapeutic strategy for treatment of various inflammatory illnesses Key words Biliverdin, bilirubin, antioxidant, anti-inflammatory, cytoprotection

In July 2023, the EMA initiated an inquiry into safety concerns after receiving approximately 150 spontaneous reports indicating potential links between drugs and suicide ideation or self-harm [72]

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Additionally, only 12.5% of the participants were African American, which raises concerns about applicability to this racial group