The discrepancy between the values of the IOM and those of recent studies on healthy people may be explained by the fact that the former represent minimal arithmetic values that assume an optimal uptake in completely healthy people, whereas the current studies represent practically determined values, which take into account real-life fluctuations
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Angiogenic signaling is a recurring theme in this area because vascular development plays an essential role in delivering oxygen, nutrients, and osteogenic precursor cells to healing bone tissue
These pathways operate both independently and in an interconnected manner, jointly determining the intensity of the host inflammatory response and balancing the immune response by regulating key transcription factors such as NF-B, MAPK, and IRF3 [286]
