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Cancer Metastasis Rev (2020) 39(3):64759

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Why This Matters for Health and Performance Understanding intrinsic factor physiology is crucial for recognizing conditions that can lead to B12 deficiency, including pernicious anemia (autoimmune destruction of parietal cells), gastric surgery, chronic PPI use, and various gastrointestinal disorders

As such, TGR5 activation stimulates secretion of GLP-1, while FXR activation reduces GLP-1 secretion, demonstrating a complex interplay between the differential bile acid pool composition and gutbrain signaling 270,271

Sayed-Ahmed MM, Aldelemy ML, Hafez MM, Al-Shabanah OA

Activation of the Nrf2ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1