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Seaton G, Smith H, Brancale A, Westwell AD, Clarkson R

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In this study, a robust hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) method was developed and optimized for the comprehensive analysis of glutathione metabolism in cell samples without chemical derivatization

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Handling these compounds correctly is a skill, and like any skill, it improves with practice and attention to detail