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What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology

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Dec 2016;17(1):60

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doi:10.1002/mnfr.201200646

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Found in human plasma and tissues, GHK-Cu declines significantly with ageleading to slower healing, reduced collagen production, and visible aging of the skin

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The expression of rHrGSTm1 was the highest in the supernatant of bacteria induced by 0.5 mM IPTG for 8 h at 37 C, and a single band of rHrGSTm1 was obtained by elution with 500 mm imidazole (Fig

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