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The target itself was validated by a 2014 Nature study showing NNMT knockdown in mouse fat and liver protected against diet-induced obesity by augmenting cellular energy expenditure (Kraus 2014, PMID 24717514) [2]

[2] [1] With neurological involvement: Hydroxocobalamin 1mg intramuscularly on alternate days until no further improvement, then maintenance injections every 2 months

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