TRIUMPH-4 Phase 3 (68 weeks, 12mg): 28.7%
Titration still follows a start low and increase approach, but spacing and step size may be individualized
2014 follow-up study was retracted in 2025, which means the foundational evidence base has significant integrity concerns that should be weighed carefully
If you notice an unusually large air pocket (taking up a significant portion of the viewing window) or if the pen appears damaged, do not use it and seek advice from your pharmacist or prescriber
Systemic Therapies: Reserved for Refractory Cases For patients with severe or refractory CHE, systemic therapies such as oral retinoids (e.g., alitretinoin) and immunosuppressants (e.g., cyclosporine, methotrexate) may be considered [91]
Moreover, MET expression levels in mice brain preparations of the striatum radiatum layer of hippocampal CA1 region are comparable in pre- and post-synaptic terminals at P7 peak in mouse