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Preclinical studies have shown a favorable safety profile, but more rigorous clinical trials are necessary to fully understand its potential side effects and risks

doi: 10.1016/S0140-6736(16)31275-2

A 4mg dose = 0.4mL = 40 units

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Smaller, frequent meals help manage gastrointestinal side effects

Furthermore, the fact that melatonins acrophase occurs several hours after the acrophase of tryptophan, its metabolic precursor, highlights the existence of a timing system [3]