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Oxidation mechanisms Lipid peroxidation Unsaturated fatty acids play a major role in cell membrane lipid peroxidation, which is driven by free radicals, and its products increase during ferroptosis

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To further confirm that the endogenous carnitine shuttle provides an acetyl-CoA pool that can be used for histone acetylation, we conducted 13 C 6 -glucose tracing in cells with knockdown of the carnitine acetyltransferases CrAT and CrOT