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If you have severe obesity, have plateaued on semaglutide or tirzepatide, or have overlapping metabolic conditions like fatty liver disease, retatrutide is the stronger intervention

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This may be helpful for those at higher risk for certain cancers, at least in theory

Additional risk factors like obesity, metabolic dysfunctions, and meal timing make nausea more likely and more severe for others

Some patients may also consider incisionless weight loss procedures to support their long-term health goals