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Supersulfides have been shown to play an important role in COPD using CARS2 heterozygous knockout mice subjected to viral infection (e.g., SARS-CoV-2) or elastase treatment [79]

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Interestingly, maternal OS biomarker levels were unaltered, perhaps due to varied conversion to toxic metabolites or lower maternal metabolic detoxification capacities, both of which can further result in continued OPC accumulation in the placental-fetal compartment, hampered efficacy of antioxidant systems, or altered repair mechanisms

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