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10 Additional observational analyses in patients with T2DM also suggested increased rates of pancreatitis and pancreatic cancer in GLP-1 RA users compared with other antidiabetic therapies

The other phase IIa study also confirmed improved glycemic control in those with obesity and T2DM, but also reported decreased body weight and improvement of blood lipids compared to placebo [44]

Berberine has potential for drug interactions based primarily on in vitro studies showing effects on cytochrome P450 enzymes, particularly CYP3A4, CYP2D6, and CYP2C9

2011 Jun;12(2):705-11