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In this study, when the protein profile of the liver and kidney was investigated with SDS-PAGE, MTX did not change the liver protein profile, but it caused a decrease in some protein bands in the kidney tissue

The blue-black to brown lesions may be punctate (macular) or diffuse and may form melanoplakiabroad sheets of stained tissue ( Figure 1 )

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Research in rat pinealocytes showed that epitalon upregulates two key enzymes in the melatonin synthesis pathway AANAT and pCREB directly stimulating endogenous melatonin production at the cellular level

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Research in both animal models and humans supports this