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The results from the randomized, crossover PROGASS trial involving 40 SSc participants suffering from chronic constipation showed that prucalopride significantly improved the number of complete bowel movements, as well as constipation and reflux scores on validated questionnaires

The proposed mechanism involves improved blood flow to exercising muscle through enhanced nitric oxide production, reduced oxidative damage via antioxidant effects, and more efficient substrate utilization during recovery [3]

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Doctors usually start patients on a low dose and slowly increase it to help reduce side effects

This article outlines what is currently known about retatrutide's adverse effects, addresses questions around libido and sexual health, and explains when to seek medical advice in the UK context

That warning is real