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Due to the constitutive expression of this variant library, we predict that this population is likely representative of silent variants that exhibit WT-like p53 activity and are therefore dropped out of the population

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In addition, accessory proteins such as COQ4, COQ8A/B, COQ9 and COQ10A/B are believed to facilitate enzyme complex assembly, substrate channeling or stabilization of the biosynthetic complex (commonly referred to as the CoQ synthome) but their precise molecular functions are still under investigation

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Based on the inclusion and exclusion criteria, a total of 6,180 reference individuals were included in this study