The impact of GLP-1 analogs on muscle mass is of particular concern, as a reduction in muscle mass can lead to sarcopenia, which negatively affects metabolic health and increases the risk of frailty in the elderly
Crucially, GLP-1 receptors are also present throughout the gastrointestinal tract , where they exert significant effects on gut motility
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Therefore, the unit for Extended Data Table 1 was person-trial
Understanding why they happen and how to manage them is not optional
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