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Interestingly, GLP-1/GLP-2 co-agonists have recently been reported to have greater glycemic and intestinotrophic effects compared to the GLP-1 receptor agonist, liraglutide 26

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Negative inotropic effects can be detected in vitro but such effects have not been seen in intact animals at therapeutic doses

Several factors can contribute to histamine intolerance, including:( 3,4) Weak digestion Inflamed intestines Bacterial infections (especially in the gut) Eating things that harm your gut, such as processed food Food allergies and food intolerances (especially gluten and cow dairy) Microbiome imbalance Nutrient deficiencies An overactive immune system Weakened adrenals (low cortisol) Chronic viral infections Mold exposure Fragrances Mood imbalances Overtraining and excessive exercise High estrogen levels If your body isnt effectively clearing histamine, it continues to circulate, causing widespread discomfort

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Semaglutide users who are eating less or experiencing GI fluid losses are at higher risk of suboptimal electrolyte status