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probably congenital History Most melanocytic naevi become apparent during childhood or early adult life The number of melanocytic naevi that an individual has is related to genetic factors and exposure to UV radiation, greater exposure normally results in the development of a larger number of naevi In later life many melanocytic naevi slowly fade away Clinical findings Acquired naevi - predominantly reticular Morphology Flat or slightly raised Generally symmetrical with a smooth border Colour - often brown but can be pink or blackish depending on skin type (darker lesions most common in skin types IV-VI)
Additionally, keratinocytes and Langerhans cells (LCs), release cytokines such as IL-10, IL-12, IL-18, IL-23, IL-17 and IL-22 and thymic stromal lymphopoietin (TSLP), leading to an enhanced Th2-type inflammatory response (48, 50, 51)