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Exenatide and lixisenatide are not recommended in severe renal impairment or end-stage renal disease, while liraglutide, semaglutide, and dulaglutide typically require no dose adjustment

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The exact timeline for noticeable weight loss may differ, but the medication is intended for long-term use, and most patients experience significant weight loss as they continue with their treatment plan

The transporters are dependent on the pH in the intestines