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This degradation is catalyzed by the ubiquitous serum enzyme dipeptidyl peptidase 4 (DPP-4), which is produced both locally in the intestine and by circulating white blood cells

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As such, HDL can be characterized as hormone-like agonists

Front Immunol (2018) 9:1438

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3 After propensity-score matching for age, BMI, breast density, race, ethnicity, and diabetes history (n=30,528), breast cancer occurred in 1.62% (247/15,264) of GLP-1 users over the study period of 3.5 years, compared with 2.31% (353/15,264) of matched non-users