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Because of the close relationship between risk factors in human metabolism and the expression of GLP-1R in the musculoskeletal system, GLP-1RAs may have great potential in the treatment of many diseases of the musculoskeletal system

Metabolism of Medications: The liver metabolizes and breaks down medications, ensuring their effectiveness and safety

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58,59 It serves as a ligand for various receptor channels on the plasma membrane, including the zinc sensing receptor (ZnR/GPR39) that regulates neuronal excitation, 60 N-methyl-D-aspartate (NMDA) receptors, 61 -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, 62 voltage-dependent calcium channels (VDCC), 63 and -aminobutyric acid A (GABAA) receptors

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First, autophagy plays a protective role by inhibiting oxidative damage and apoptosis in CuSO 4 -induced testicular injury and spermatogenesis disruption, and second, autophagy plays an adverse role by promoting ferroptosis, thus aggravating the toxicity caused by CuSO 4 [100]