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The FDA has evaluated the safety and effectiveness of these containers and has cleared them for use by health care professionals and the public to help reduce the risk of injury and infections from sharps

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[27] Opioid-induced constipation Clinical features Recent initiation of an opioid or dose adjustment New or worsening constipation Fecal impaction may be present Physical examination typically normal Diagnostics [8] Clinical diagnosis Rome IV diagnostic criteria for OIC Recent initiation of opioid treatment or a dose increase AND 2 of the characteristic clinical features of functional constipation: Passage of spontaneous bowel movement 20% of the markers are retained

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Shen, H., Jiang, L., Lin, J