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In a different study, toll-like receptors (TLRs) and type I and II interferon (IFN) receptors as well as their downstream signaling components were identified in taste tissue [166] The IFN signaling pathway was activated by administration of TLR ligands (lipopolysaccharide and double-stranded RNA polyinosinic:polycytidylic acid) and upregulates the expression of IFN-inducible genes in taste buds

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