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3235 To provide some context, a weight loss of up to about 5% was seen with 4.5 mg of dulaglutide, 7.2% with 2 mg of semaglutide, 10.6% with 2.4 mg of semaglutide in adults with overweight or obesity and T2DM (STEP 2), 35 and 12% with 15 mg of tirzepatide, following treatment periods of 40 to 68 weeks

Four principles stand out: Nutrient density as north star: When people eat less, every bite matters more

Probiotics have been shown to be potentially effective in reducing diarrhea duration and frequency, though these data were gathered on children and may not be applicable to adults on semaglutide

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However, there are alternative medications to treat diabetes, such as insulin, Metformin, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose co-transporter 2 (SGLT2) inhibitors, meglitinides, thiazolidinediones and alpha-glucosidase inhibitors

As always, it is essential to consult with a healthcare professional to determine the suitability of retatrutide for individual needs