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Meanwhile, adults diagnosed with type 2 diabetes before 40 should be offered dual therapy before a GLP-1 receptor agonist is considered, while patients with chronic kidney disease should have tailored recommendations based on their kidney function

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An Aib substitution at position 8 blocks DPP-4 enzyme cleavage

The results were promising: the triple agonists were more effective at reducing body weight and increasing energy expenditure compared to GLP-1 receptor mono-agonists and GLP-1 receptor/GIP receptor co-agonists

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