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Similarly, treatment with linagliptin resulted in significant improvement in the insulinogenic index in the high GLP-1 prediabetes [LS-mean change from baseline 23.53 (95% CI 13, 34.06)]

Transient or occasional reflux isnt something to worry about

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In clinical trials, participants who started at 2mg and escalated every 4 weeks through 4mg, 8mg, and finally 12mg experienced a gradual onset of appetite suppression

And staying hydrated helps mitigate some of the drugs' side effects, like nausea and headaches