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Whether this pattern persists beyond 52 weeks, whether it is dose-dependent, and whether it is reversible upon discontinuation of therapy are questions that remain unanswered and need to be addressed in larger, longer-duration trials

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For example, the cellular functions of actin are mediated by reversible S-glutathionylation (58) such that impairment of actin S-glutathionylation alters stress fiber formation and cytoskeleton organization (83)

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