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Abbreviations AF: Allele frequency CMN: Congenital melanocytic nevus CMNS: Congenital melanocytic nevus syndrome CNS: Central nervous system CpG: Cytosine (C)phosphate (p)Guanine (G) CSF: Cerebrospinal fluid DNA: Deoxyribonucleic acid MEK: MAPK/ERK kinase (MAPK = Mitogen-Activated Protein Kinase) MITF1 : Microphthalmia-Associated Transcription Factor 1 MPRAGE: Magnetization-Prepared Rapid Gradient-Echo MRI: Magnetic resonance imaging NGS: Next generation sequencing NRAS : Neuroblastoma RAS proto-oncogene PTEN : Phosphatase and tensin homolog RAF: RAF (Rapidly Accelerated Fibrosarcoma) serine/threonine kinases RAS : RAS (RAt Sarcoma) proto-oncogene TERT : Telomerase reverse transcriptase TERT-p : Telomerase reverse transcriptase promoter TSE: Turbo spin echo UV: Ultraviolet References Kinsler VA, Thomas AC, Ishida M, Bulstrode NW, Loughlin S, Hing S et al (2013) Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS

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10.1038/nprot.2015.017 97 MiessH.DankworthB.GouwA