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Effective wind-down activities include reading (physical book, not a screen), gentle stretching or yoga, meditation or deep breathing exercises, warm bath or shower (the subsequent cooling helps initiate sleep), journaling (particularly effective for anxiety-driven insomnia as it externalizes racing thoughts), and preparing for the next day (reduces morning-related anxiety)

Other studies show that Cotaduide could intervene and reverse NASH through improving metabolism in the liver including lipid and glucose metabolism via GCGR in mice, suggesting that Cotaduide may be a potential and viable therapeutic as a targeted drug intervention to reverse disease progression of NASH (131)

In RGC cell lines and in vivo , Zhou and colleagues [89] showed hyperglycemia decreased the viability of RGCs and increased mitophagy beyond the basal levels required for homeostasis

These are not small losses