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GLP-1 Receptor Agonists and Sight-Threatening Diabetic Retinopathy and Other Ocular Complications Ramsey DJ et al

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Potency loss can also occur without visible change, so solutions stored beyond the validated shelf life must be discarded regardless of appearance

The hypoglycaemia risk arises because IGF-1R cross-activates the insulin receptor at supraphysiologic concentrations, stimulating GLUT4 translocation and glucose uptake [3]